Slack-activating compounds and their medical use

A compound, wherein the compound has the formula I:

• or a salt, complex, diastereomer, enantiomer and/or tautomer of thereof,
• wherein
• A is one or two substituents independently selected from —H, —F, —Cl, —Br, —I, —CF3, —OCF3, —CF2H, and —OCF2H;
• B is one or two substituents independently selected from —F, —Cl, —Br, —I, —CF3, —OCF3, —CF2H, and —OCF2H;
• X is selected from —S-and-O—;
• m is 0 to 3;
• Y is selected from
• —H;
• a nitrile group,
• a 5- to 6-membered unsaturated heterocycle comprising 3 hetero atoms that are selected from O and N, preferably wherein 2 or 3 heteroatoms are nitrogen, wherein the heterocycle is mono or di-substituted with ═S or ═O, preferably with ═O;
• or
• a linear —C1-3alkyl, wherein a, preferably one, —(CH2)— of the linear —C1-3alkyl is optionally monosubstituted with —OH, and wherein the terminal —CH3 of the linear-C1-3alkyl is monosubstituted with —OR1 or —SR1, preferably —OR1, wherein R1 is H, —(CH2)—COOH or —(CH2)—(CH2)—OH;
• or
• —(CH2)i—CX1R2, wherein
• X1 is ═NR3 or ═O, wherein R3 is —H or —OH.
• i is 0 or 1, and
• R2 is —OR4 or —NR5R6, wherein R4 is —H or —C1-2alkyl;
• wherein R5 and R6 are independently selected from —H or -methyl;
• herein denoted as “Z”, is an aliphatic group comprising 1 or 2 heterocycles which comprise together two nitrogen atoms,
• wherein the first of the two nitrogen atoms connects Z to
• of formula I and the second of the two nitrogen atom connects Z to
• of formula I, preferably to
• and wherein
• the two nitrogen atoms are each a heteroatom in one of two connected 4-membered heterocycles (each heterocycle having no more than one heteroatom), wherein the two interconnected 4-membered heterocycles form a spirocylce, preferably wherein the 4-membered heterocycle with the first nitrogen atom is connected via a shared carbon atom to the 4-membered heterocycle with the second nitrogen atom, thus forming a spirocycle with two heteroatoms that are the two nitrogen atoms;
• or
• the first of the two nitrogen atoms is connected to a 4-membered heterocycle with one heteroatom, wherein the second of the two nitrogen atoms is the heteroatom in the 4-membered heterocycle that the first of the two nitrogen atoms is connected to;
• wherein the first nitrogen atom is further substituted with methyl;
• or
• the two nitrogen atoms are heteroatoms in a 6- to 7-membered heterocycle with two heteroatoms, wherein the heterocycle is optionally substituted, preferably monosubstituted, with methyl;
• and wherein the compound is not any of