Small molecule inhibitors of mammalian slc6a19 function

A compound of Formula (I):

• wherein:
• L1 is absent or selected from -alkyl-, -hydroxyalkyl-, -cycloalkyl-, and -heteroaryl-CH2—;
• L3 is absent or —C(O)—;
• X1 and X2 are independently selected from —H, alkyl, haloalkyl, cycloalkyl, heteroalkyl, cycloheteroalkyl, alkyl-cycloalkyl, heterocyclyl, and aryl;
• provided that X1 and X2 are not both —H;
• Y1 is selected from aryl and heteroaryl;
• Y2 is selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —NH(Y2′), and —N(Y2″)2;
• Y2′ is selected from —H, —OH, alkyl, alkoxy, alkoxyalkyl, hydroxyalkyl, haloalkyl, and cycloalkyl;
• each Y2″ is independently alkyl, or both instances taken together with the nitrogen atom to which they are bonded form a 5 or 6 membered heterocyclyl;
• Y3, Y3′, Y4, Y4′, Y5, and Y′ are independently selected from —H, alkyl, haloalkyl, heteroalkyl, halo, hydroxyl, alkoxy, —NH(Z′), and —N(Z″)2;
• or Y3 and Y4 or Y3′ and Y4′ taken together with the carbon atoms to which they are bonded form an an optionally substituted fused C3-C6 cycloalkyl;
• or Y4 and Y5 or Y4′ and Y5′ taken together with the carbon atoms to which they are bonded form an an optionally substituted fused C3-C6 cycloalkyl;
• provided that the compound comprises no more than one optionally substituted fused C3-C6 cycloalkyl;
• Z2′ is selected from —H, —OH, alkyl, alkoxy, alkoxyalkyl, hydroxyalkyl, haloalkyl, and cycloalkyl;
• and
• each Z2″ is independently alkyl, or both instances taken together with the nitrogen atom to which they are bonded form a 5 or 6 membered heterocyclyl;
• or a pharmaceutically acceptable salt thereof.