Compounds and method for upregulation of p53 through induction of mdm2 degradation

A compound having the structure of

• wherein
• (a) R1 and R1′ are independently a hydrogen, a hydroxyalkyl, or carbonyl (e.g., a keto), wherein at least one of R1 and R1′ is not hydrogen;
• (b) R2 is an electrophilic group;
• (c) R5 is a hydrogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, or a substituted or unsubstituted alkynyl;
• (d) R3, R4, R2′, R3′, and R4′ are independently a hydrogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, a substituted or unsubstituted aryl, a substituted or unsubstituted polyaryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted heteropolyaryl, a substituted or unsubstituted heterocyclyl, a halogen, a hydroxyl, an amino, an amido, an azo, an alkoxy, a polyether, a thiol, a cyano, a nitro, or a carbonyl;
• (e) each substituent is independently a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, a substituted or unsubstituted heterocyclyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted polyaryl, a substituted or unsubstituted polyheteroaryl, a substituted or unsubstituted aralkyl, a carbonyl, an alkoxy, a halogen, a hydroxyl, a phenoxy, a thiol, an alkylthio, a phenylthio, an arylthio, a cyano, an isocyano, a nitro, an carboxyl, an amino, an amido, an azido, an oxo, a silyl, a sulfinyl, a sulfonyl, a sulfonic acid, a phosphonium, a phosphanyl, a phosphoryl, or a phosphonyl.