Compositions of and methods of making ultra-pure tricaprilin
AssigneeCerecin Australia Pty Limited
InventorAikun Julie LIU
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Abstract
The present disclosure provides methods of producing ultra-pure tricaprilin and compositions comprising the ultra-pure tricaprilin. The disclosure also provides methods of using the compositions for the treatment of diseases.
Claims24
An ultra-pure composition comprising at least about 99.2% by weight tricaprilin and about 0.8% by weight or less of impurities,
- wherein the tricaprilin is a tri-ester tricaprilin;
- and
- wherein the impurities comprise one or more of 2-monochloropropanediol, 2-monochloropropanediol monoester, 2-monochloropropanediol diester, 3-monochloropropanediol, 3-monochloropropanediol monoester, 3-monochloropropanediol diester, or any combination thereof.
A method of making an ultra-pure composition of tricaprilin, the method comprising:
- (a) feeding caprylic acid, a concentrated acid, glycerol, and water into a first reactor;
- (b) reacting caprylic acid, the concentrated acid, glycerol, and water to form a product mixture comprising tricaprilin and impurities in the first reactor, wherein the impurities comprise unreacted reactants and optionally undesired side products;
- (c) adding an organic solvent and an aqueous solution of a basic salt to a second reactor forming a biphasic mixture comprising a top organic phase and a bottom aqueous phase;
- (d) adding portions of the product mixture from step (b) into the biphasic mixture in step (c) to remove the unreacted reactants, wherein the unreacted reactants are in the aqueous phase;
- (e) removing the bottom aqueous phase from the second reactor;
- (f) treating the top organic phase with charcoal;
- (g) distilling off the organic solvent and leaving tricaprilin and impurities in the second reactor;
- and
- (h) recrystallizing the tricaprilin and impurities to remove the impurities and form the ultra-pure tricaprilin.
A method of prophylactically or therapeutically treating a disease or a disorder in a subject in need thereof, the method comprising administering a composition comprising ultra-pure tricaprilin to the subject.
Dependencies are inferred from the claim text.