Novel dimethylchalcone derivative
AssigneesChung Ang University Industry Academic Cooperation Foundation, Seoul National University R&Db Foundation, Seoul National University Hospital
InventorsKwang Yong PARK, Kyong Soo PARK
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Abstract
Provided are novel compounds based on the meta-substitution of 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (DMC). According to the presently claimed subject matter, novel DMC derivatives that are meta-substituted using cheap phloroglucinol or the like as a starting material can be simply and efficiently synthesized. Specifically, DMC derivatives according to the presently claimed subject matter were confirmed to have a good fatty acid oxidation effect compared to existing DMC derivatives, and thus are expected to be used as a therapeutic material for metabolic diseases.
Claims12
A compound represented by the following Chemical Formula I, an isomer thereof, or a pharmaceutically acceptable salt thereof:
- wherein:
- R0, R1, and R2 are each independently a hydroxyl group (OH), a methoxymethoxy group (OCH2OCH3;
- OMOM), or a C1-C10 alkoxy group;
- R8 and R9 are each independently a C1-C10 alkyl group;
- R3 to R7 are each independently any one selected from the group consisting of a halogen, hydrogen (H), deuterium (D), a thiol group (SH), a cyano group (CN), a nitro group (NO2), a substituted or unsubstituted amino group (NH2), a substituted or unsubstituted C1-C10 alkylthio group, a substituted or unsubstituted C1-C10 alkylsulfonyl group, a substituted or unsubstituted C1-C10 alkylsulfoxy group, a substituted or unsubstituted C1-C10 alkyl group, a substituted or unsubstituted C2-C10 alkenyl group, a substituted or unsubstituted C2-C10 alkynyl group, and a substituted or unsubstituted C6-C20 aryl group;
- and
- the term “substituted or unsubstituted” refers to being unsubstituted or substituted with one or more substituents selected from the group consisting of a halogen group, a nitrile group, a nitro group, a hydroxyl group, a carbonyl group, an ester group, an imide group, an amino group, a phosphine oxide group, an alkoxy group, an aryloxy group, an alkylthioxy group, an arylthioxy group, an alkylsulfoxy group, an arylsulfoxy group, an alkylsulfonyl group, an arylsulfonyl group, a silyl group, a boron group, an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, an aryl group, an aralkyl group, an aralkenyl group, an alkylaryl group, an alkylamine group, an aralkylamine group, a heteroarylamine group, an arylamine group, an arylphosphine group, and a heterocyclic group;
- provided that at least any one of R4 and R6 is not hydrogen;
- at least any one of R0, R1, and R2 is not OH;
- and
- when R0 and R1 are both OMe or both OMOM, R2 is not OH or OMOM.
Dependencies are inferred from the claim text.