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US 2026/0257221 A1Published application
Fluidics, microplate, and method including integrated resistive heating
AssigneePleno, Inc.
InventorsPaul Anderson, Ludovic Vincent
Life of this patent
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Abstract
The subject matter of the present disclosures relates generally to the processing of biological materials and more particularly to a fluidics system, microplate, and method including integrated resistive heating.
Claims20
A method for heating a sample comprising:
- (a) placing a sample in a microplate, wherein the microplate comprises a well structure comprising at least one well configured to support the sample,
- (b) integrating a heater into the microplate, wherein the heater is configured to provide localized resistive heat to the well structure of the microplate by heating both the well structure and the sample,
- (c) applying a voltage to the well structure, causing the well structure to generate a localized resistive heat, and
- (d) locally heating the sample using the localized resistive heat, wherein the localized resistive heat is dependent on an applied voltage and resistive properties of a resistive heating layer of the well structure, and wherein the localized resistive heat does not substantially provide heat to a surrounding environment of the well structure.
1 more element
A microplate used for heating a sample, the microplate comprising:
- (a) a well structure comprising a plurality of wells configured to support a plurality of samples, wherein the well structure comprises a material comprising polycarbonate, copolymer, cyclic olefin copolymer or a combination thereof,
- (b) a heater integrated into the microplate, wherein the heater integrated into the microplate is configured to provide localized resistive heat to the well structure by heating both the well structure and the plurality of samples, wherein the localized resistive heat does not substantially heat a surrounding environment of the microplate.
A fluidics system for processing a sample, comprising a microplate for heating a sample, the microplate comprising:
- (a) a well structure comprising at least one well configured to support the sample,
- (b) a heater integrated into the microplate, wherein the heater comprises an optically transparent substrate and a resistive heating layer patterned thereon, and wherein the heater is configured to provide localized resistive heat to the well structure by locally heating both the well structure and the sample, and
- (c) a fluidics instrument comprising the microplate and a surrounding environment of the microplate, wherein the surrounding environment of the microplate comprises one or more of
- (i) a mechanical stage supporting the microplate, wherein the mechanical stage is operatively coupled to the microplate,
- (ii) a liquid handling system arranged to deposit and remove liquid from the microplate, wherein the liquid handling system is positioned above the microplate,
- (iii) a detection system configured to detect materials from the wells of the well structure,
- (iv) a thermal control unit operatively coupled to a volage source, or
- (v) a computing system configured to manage the operations of the mechanical stage, the liquid handling system, and the detection system, wherein the localized resistive heat does not substantially heat the surrounding environment of the microplate.
5 more elements
Dependencies are inferred from the claim text.