Filler for ion exchange chromatography, method for producing same, and method for measuring hemoglobin component

Abstract

The disclosure provides a packing material for ion exchange chromatography that has very high separation performance even at reduced column pressure and is useful for measurement of hemoglobins, particularly hemoglobin A1c and the like, and a production method that enables efficient and easy production of the packing material. The disclosure also provides a hemoglobin measurement method that enables measurement of hemoglobins with very high accuracy. The packing material of the disclosure is used for ion exchange chromatography, the packing material including core-shell particles, each core-shell particle including a core and a shell covering at least part of the core, and including a cation exchange group on a surface of the shell, the packing material having a CV value (%) of 18% or less, where the CV value is represented by the following formula (1): CV value (%)=(standard deviation of particle size/average particle size)×100.

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