Devices and methods for delivering synergistic active agents to target sites
OwnerPaul Rucinski, Michael A. Gil +1inventors
InventorsPaul Rucinski, Michael A. Gil, Venkata Katragadda
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Abstract
Novel, inexpensive, and highly effective methods and devices for convenient and effective wound irrigation are described herein. Methods and devices disclosed herein utilize a synergistic combination of two or more antiseptic agents to reduce contact time, enhance antimicrobial effects, and reduce the likelihood of allergy and other side effects from the antiseptic agents in subjects. In one embodiment, devices include a discharge means for a reservoir housing containing irrigation solution wherein the discharge means has one or more specifically designed nozzles through which a sufficient volume of the irrigation solution can pass at an appropriate pressure.
Claims21
1-20. (canceled)
A wound irrigation device comprising a reservoir housing containing a wound irrigation solution, wherein the wound irrigation solution comprises:
- (i) sterile water, purified water, or water for pharmaceutical purposes;
- (ii) a chlorhexidine at a concentration that is between about 100 μg/mL to about 5 mg/mL;
- and
- (iii) lauroyl arginate ethyl ester (LAE) or a pharmaceutically acceptable salt thereof at a concentration that is between about 1 μg/mL to about 200 μg/mL,
- wherein the wound irrigation device comprises a discharge means that directs a stream of the wound irrigation solution when the reservoir housing is compressed, wherein the reservoir housing is made of a resilient compressible material.
Dependencies are inferred from the claim text.