Injectable hydrogel material formed in-situ and use thereof in the preparation of tissue repair formulations

Abstract

An injectable hydrogel material formed in-situ of the present invention includes two fluid components: component A and component B, wherein component A is an activated linker solution, and component B is a collagen and/or gelatin fluid. The hydrogel material of the present invention is prepared in use. First, a cross-linking activator is used to activate the linker to give component A. During this process, a portion of the cross-linking activator is consumed, thus reducing the amount of cross-linking activator in contact with tissues. Subsequently, component A and component B are mixed, and the macromolecules in the components undergo chemical cross-linking to form a gel. A neutralizing agent is introduced into component B to consume the cross-linking activator in the material during the chemical cross-linking of the macromolecules and a period thereafter.

Dependencies are inferred from the claim text.