Medicinal adhesive compositions

A medical product, comprising:

• a composition including
• a plurality of substituted 1,2-dithiolane monomers, the substituted 1,2-dithiolane monomers functional to polymerize through a ring-opening reaction to form a polydisulfide polymer having
• a first active thiol end and a second active thiol end;
• and,
• a plurality of repeating units having a substituted dithioalkyl structure from the ring opening reaction as follows
• wherein,
• n is 3;
• each Ri and Rk is independently selected from the group consisting of H;
• alkyl, cycloalkyl, alkenyl, alkynyl, and aryl groups, each of the groups having from 1-8 carbons;
• hydroxylated alkyl, cycloalkyl, alkenyl, alkynyl, and aryl groups, each of the groups having from 1-8 carbons;
• and, carboxylated alkyl, cycloalkyl, alkenyl, alkynyl, and aryl groups, each of the groups having from 1-8 carbons;
• wherein, i and k are integers, and at least one Ri or Rk in each repeating unit includes a carbonyl functionality;
• and,
• m is an integer selected to match a desired molecular weight of the polymer;
• a plurality of stabilizer molecules configured to stabilize the first active thiol end of the polymer, the plurality of stabilizer molecules being the substituted cyclic disulfide molecules derivatized to include a functional group that forms a first labile bond with the first active thiol end, the first labile bond selected from the group consisting of a thioester bond, a thiocarbamate bond, and a thioether bond;
• and,
• a bioactive agent;
• wherein, the polydisulfide polymer is formed by reacting the plurality of monomers and the plurality of stabilizers in the liquid composition;
• adheres to a biological tissue in water;
• is biocompatible and biodegradable;
• and,
• releases the bioactive agent for delivery to a target tissue.