Therapeutic hydrogels
AssigneeVivos, Inc., d/b/a Advanced Medical Isotope Corporation
InventorsJohn Solomon GARNER, David SWANBERG, Bradley WEEKS, James DUNCAN, Michael KORENKO, Rebecca Anne IMMEL
Life of this patent
Estimating the term…
Abstract
Disclosed herein are reabsorbable therapeutic hydrogels comprising PLGA-g-PEG polymers. It is believed that reabsorption of the hydrogel may allow healthy tissue to replace the hydrogel in healing tissues. It has been discovered that a molar ratio of lactic acid (LA) to glycolic acid (GA) in the PLGA-g-PEG polymer from about 65:35 to about 85:15 (LA:GA) is preferred for use in forming the reabsorbable therapeutic hydrogels described herein.
Claims34
A biodegradable thermogel suspension that forms a gel at a temperature of about 20° C. to about 40° C. comprising:
- one or more PLGA-g-PEG polymers, which are synthesized under conditions substantially free of water molecules and oxygen molecules, then dissolved in an aqueous buffer solution;
- wherein the molar ratio of lactate monomer (LA) to glycolate monomer (GA) in the one or more PLGA-g-PEG polymers is individually from about 65:35 to about 85:15;
- and
- wherein the biodegradable thermogel biodegrades with a half-life of from about 1 day to about 365 days or about 10 to about 50 days.
A biodegradable radioactive thermogel suspension that forms a gel at a temperature of about 20° C. to about 40° C. comprising:
- one or more PLGA-g-PEG polymers, which are synthesized under conditions substantially free of water molecules and oxygen molecules, dissolved in an aqueous buffer solution;
- wherein the molar ratio of lactate monomer to glycolate monomer in the one or more PLGA-g-PEG polymers is individually from about 65:35 to about 85:15;
- and
- a plurality of chemically isolated radioactive particles suspended in the thermogel, wherein each chemically isolated radioactive particle includes a cation and a functional group;
- wherein the plurality of chemically isolated radioactive particles are between 0.03 μm and 10 μm in diameter;
- wherein the chemically isolated radioactive particles have water solubility of less than 1×10−6 mole/liter;
- and
- wherein the biodegradable radioactive thermogel biodegrades with a half-life of from about 1 day to about 365 days, or about 10 days to about 50 days.
Dependencies are inferred from the claim text.