Liquid composition of compound i, preparation method therefor, and application thereof
AssigneeBeijing Sinotau International Pharmaceutical Technology Co., Ltd.
InventorsYue WANG, Ying ZHANG, Aili ZHANG, Xinsheng XU
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Abstract
The present application provides a liquid composition of Compound I, a preparation method therefor, and an application thereof, wherein same is selected from one or more among vitamin C, sodium vitamin C, and gentisic acid. By optimizing process parameters and technological process, the method of the present application can be applied to large-scale production, and the product prepared has high radiochemical purity, high activity and concentration, good product stability, high and stable yield or productivity.
Claims16
A liquid composition of Compound I, comprising one or more selected from the group consisting of vitamin C, sodium vitamin C, and gentisic acid;
- the Compound I is 2-tert-butyl-4-chloro-5-((3-((4-((2-(2-fluoro[18F]ethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)methyl)benzyl)oxy)pyridazin-3(2H)-one.
A reagent kit for automated preparation of a liquid composition of Compound I, wherein the reagent kit comprises a reaction flask and a prescription bottle;
- the reaction flask includes reaction flask R1, reaction flask R2, and reaction flask R3;
- wherein the reaction flask R1 is used to hold the eluent for eluting 18F ion;
- the reaction flask R2 is used to hold a solution of Compound I precursor for the 18F ion nucleophilic substitution reaction;
- the reaction flask R3 is used to hold reagents for diluting the crude products and rinsing the reaction system;
- the prescription bottle includes prescription bottle P1 and prescription bottle P2;
- wherein the prescription bottle P1 is used to transfer the reaction product of 18F ion nucleophilic substitution reaction;
- the prescription bottle P2 is used to hold substances used to stabilize the reaction product of 18F ion nucleophilic substitution reaction.
Dependencies are inferred from the claim text.