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US 2026/0256952 A1Published application
Dual-modal tumor imaging using functionalized iron-oxide nanoparticles for mri and fluorescence imaging
AssigneeUniversity of South Florida
InventorsKevin Secades, Diane Allen-Gipson
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Abstract
Disclosed herein are systems and methods for facilitating tumor discovery without the use of radioisotopes.
Claims20
A method for providing a tumor discovering compound, comprising:
- synthesizing iron oxide (Fe3O4) nanoparticles (IONPs);
- coating the IONPs with a poly(ethylene glycol) (PEG) layer, wherein the PEG layer comprises a folic acid component (PEG-FA) to provide a PEG-FA coated IONP (PEG-FA-IONP);
- purifying the PEG-FA-IONPs;
- labeling the PEG-FA-IONPs with a fluorescent chromophore to provide a PEG-FA-dye-IONP;
- and
- purifying the PEG-FA-dye-IONPs.
3 more elements
A method of identifying cancerous cells in a body, comprising:
- introducing a fluorescent chromophore-labeled-cancer-specific-ligand-functionalized nanoparticle into the body;
- binding the fluorescent chromophore-labeled-cancer-specific-ligand-functionalized nanoparticle to a cell overexpressing folate receptors;
- and
- imaging the cells overexpressing folate receptors having the fluorescent chromophore-labeled-cancer-specific-ligand-functionalized nanoparticle bound thereon,
- wherein imaging comprises contrast-enhanced magnetic resonance imaging (MRI), optical imaging, or a combination thereof to specify a tumor cell.
2 more elements
A dual-modal tumor imaging system, comprising:
- an iron oxide (Fe3O4) nanoparticle (IONP);
- a poly(ethylene glycol) (PEG) layer disposed on the IONP, wherein the PEG layer comprises a folic acid component (PEG-FA);
- and
- a fluorescent chromophore conjugated onto a portion of the folic acid component.
1 more element
Dependencies are inferred from the claim text.