Method for promoting myogenesis and skeletal muscle recovery
AssigneeUniversity of Miami
InventorsZhao-Jun Liu, Omaida Velazquez
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Abstract
The disclosure relates to, in part, to methods of inducing myogenesis in non-ischemic atrophied muscle in a subject in need thereof, comprising administering to the subject a hybrid adeno-associated virus (AAV) comprising a nucleotide sequence encoding an E-selectin, in amount effective to induce myogenesis in the non-ischemic atrophied muscle of the subject.
Claims22
A method of inducing myogenesis in non-ischemic atrophied muscle in a subject in need thereof, comprising administering to the subject a hybrid adeno-associated virus (AAV) comprising a nucleotide sequence encoding an E-selectin, in amount effective to induce myogenesis in the non-ischemic atrophied muscle of the subject.
A method of treating a muscle tear in non-ischemic muscle tissue in a subject in need thereof, comprising administering to the subject a hybrid adeno-associated virus (AAV) comprising a nucleotide sequence encoding an E-selectin, in amount effective to treat the muscle tear in the subject.
A method of improving the outcome of a connective tissue reattachment procedure in a subject in need thereof comprising administering to the subject a hybrid adeno-associated virus (AAV) comprising a nucleotide sequence encoding an E-selectin in an amount effective to improve the outcome of procedure, wherein the subject is not suffering from critical limb ischemia.
Dependencies are inferred from the claim text.