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US 2026/0256928 A1Published application
Peptide saporin conjugate for the treatment of cancer
AssigneeSRI International
InventorsKathlynn C. Brown, Curtis Allred, Michael McGuire
Life of this patent
Estimating the term…
Abstract
Disclosed herein are compositions comprising one or more a molecular guidance system (MGS) peptides and compounds comprising a cytotoxic agent conjugated to molecular guidance system (MGS) peptide. Also described herein, are methods of targeting an intracellular target in a cell in vitro or in a subject comprising contacting the cell with or administering a composition to the subject.
Claims14
A molecular guidance system (MGS) peptide of amino acid sequence selected from:
- (SEQ ID NO:
- 19)
- THGNKHQSWTYPSEINHKNY,
- (SEQ ID NO:
- 23)
- NLADTWTQTQQHDFHVLRGT,
- (SEQ ID NO:
- 24)
- SVEYWGERMYYDVMESLGFS,
- (SEQ ID NO:
- 25)
- FAAKRAEWWDPGQLWDAVWN,
- (SEQ ID NO:
- 26)
- QEALEEWFWKMMPWSGPSGQ,
- (SEQ ID NO:
- 27)
- TWTDFGQWPWPFGAEGTRAF,
- (SEQ ID NO:
- 28)
- MDGATWWTQLDPLLVWEGET,
- (SEQ ID NO:
- 29)
- SADWFQGPAEWLLEGWMGPL,
- (SEQ ID NO:
- 46)
- LTVHGRGPEYNPSWNRRAFP,
- (SEQ ID NO:
- 57)
- SAKTAVSQRVWLPSHRGGEP,
- (SEQ ID NO:
- 58)
- KSREHVNNSACPSKRITAAL,
- (SEQ ID NO:
- 60)
- TGGETSGIKKAPYASTTRNR,
- (SEQ ID NO:
- 61)
- SHHGVAGVDLGGGADFKSIA,
- (SEQ ID NO:
- 62)
- SNSPLGLKDEATQRLVLEQAKWLA,
- (SEQ ID NO:
- 63)
- GPEDTSRAPENQQKTFHRRW,
- (SEQ ID NO:
- 64)
- SGETGSNLVGHELDFRPGSPSP,
- (SEQ ID NO:
- 65)
- RYSPAATAEGRSVSKELLRV,
- (SEQ ID NO:
- 66)
- GQELGAWTRSKGPEVQTSVL,
- (SEQ ID NO:
- 67)
- ASTWRGTSAGGNRLEKMEVT,
- (SEQ ID NO:
- 68)
- LSGTPERSGQAVKVKLKAIP,
- (SEQ ID NO:
- 69)
- GAWEAVRDRIAEWGSWGIPS,
- (SEQ ID NO:
- 70)
- AMDMYSIEDRYFGGYAPEVG,
- and
- (SEQ ID NO:
- 79)
- HAVPQSFYT.
67 more elements
A composition comprising a cytotoxic agent conjugated to a molecular guidance system (MGS) peptide selected from:
- (SEQ ID NO:
- 19)
- THGNKHQSWTYPSEINHKNY,
- (SEQ ID NO:
- 23)
- NLADTWTQTQQHDFHVLRGT,
- (SEQ ID NO:
- 24)
- SVEYWGERMYYDVMESLGFS,
- (SEQ ID NO:
- 25)
- FAAKRAEWWDPGQLWDAVWN,
- (SEQ ID NO:
- 26)
- QEALEEWFWKMMPWSGPSGQ,
- (SEQ ID NO:
- 27)
- TWTDFGQWPWPFGAEGTRAF,
- (SEQ ID NO:
- 28)
- MDGATWWTQLDPLLVWEGET,
- (SEQ ID NO:
- 29)
- SADWFQGPAEWLLEGWMGPL,
- (SEQ ID NO:
- 46)
- LTVHGRGPEYNPSWNRRAFP,
- (SEQ ID NO:
- 57)
- SAKTAVSQRVWLPSHRGGEP,
- (SEQ ID NO:
- 58)
- KSREHVNNSACPSKRITAAL,
- (SEQ ID NO:
- 60)
- TGGETSGIKKAPYASTTRNR,
- (SEQ ID NO:
- 61)
- SHHGVAGVDLGGGADFKSIA,
- (SEQ ID NO:
- 62)
- SNSPLGLKDEATQRLVLEQAKWLA,
- (SEQ ID NO:
- 63)
- GPEDTSRAPENQQKTFHRRW,
- (SEQ ID NO:
- 64)
- SGETGSNLVGHELDFRPGSPSP,
- (SEQ ID NO:
- 65)
- RYSPAATAEGRSVSKELLRV,
- (SEQ ID NO:
- 66)
- GQELGAWTRSKGPEVQTSVL,
- (SEQ ID NO:
- 67)
- ASTWRGTSAGGNRLEKMEVT,
- (SEQ ID NO:
- 68)
- LSGTPERSGQAVKVKLKAIP,
- (SEQ ID NO:
- 69)
- GAWEAVRDRIAEWGSWGIPS
- (SEQ ID NO:
- 70)
- AMDMYSIEDRYFGGYAPEVG,
- and
- (SEQ ID NO:
- 79)
- HAVPQSFYT.
67 more elements
Dependencies are inferred from the claim text.