Oligonucleotides for use in modulating immune responses against hepatitis b viral infection
AssigneeAusperbio Therapeutics Inc.
InventorsGuofeng CHENG, Cheng Yong YANG
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Abstract
Provided herein are vaccine compositions comprising an oligonucleotide and a Hepatitis B viral antigen, either present in the same composition, or in separate compositions, useful for prevention or treatment of Hepatitis B viral infection in a subject. The vaccine compositions can exert a sustained immunomodulatory effect and lead to the reduction of HBV antigen levels in an infected subject. Also provided herein are methods of making and use thereof.
Claims38
A vaccine composition comprising at least one oligonucleotide and at least one hepatitis B virus (HBV) antigen.
28-30. (canceled)
A method of eliciting an immune response to a HBV antigen in a subject suffering from an HBV infection, or a HBV-related disease, disorder, or condition with a vaccine treatment, comprising administering to the subject an oligonucleotide and a hepatitis B virus (HBV) antigen
A method of treating or preventing an HBV infection, or a HBV-related disease, disorder, or condition in a subject with a vaccine treatment, comprising administering to the subject an oligonucleotide and a hepatitis B virus (HBV) antigen.
39-75. (canceled)
A kit comprising an oligonucleotide and a hepatitis B virus (HBV) antigen.
Dependencies are inferred from the claim text.