Polynucleotide compositions and uses thereof
AssigneePfizer Inc.
InventorsYe Che, Laurent Olivier Chorro, Fernando Martin Diaz, Robert George Konrad Donald, Jin Li, Natalie Clare Silmon de Monerri, Raphael Simon
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Abstract
The invention relates to RNA molecules encoding an E. coli fimbrial H antigen (FimH). The present disclosure further relates to compositions comprising the RNA molecules formulated in a lipid nanoparticle (RNA-LNP). The present disclosure further relates to the use of the RNA 5 molecules, RNA-LNPs and compositions for the prevention of E. coli infection, including urinary tract infection.
Claims66
A ribonucleic acid polynucleotide (RNA) molecule comprising at least one open reading frame (ORF) encoding a FimH antigenic polypeptide.
The RNA molecule of claim 21, wherein the 5′ UTR comprises nucleotides having SEQ ID NO:
- 75.
Dependencies are inferred from the claim text.