Hydrogels containing aldehyde groups for controlled release of bacteriophages and antibiotics to treat infections
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsOvijit Chaudhuri, Paul L. Bollyky, Yung-Hao Lin, Qingquan Chen, Tejas Dharmaraj
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Abstract
Provided herein are hydrogels that include a plurality of amine-containing antimicrobial agents within the interiors of the hydrogels. The antimicrobial agents are connected to the hydrogel interiors via dynamic covalent imine bonds, and the hydrogel is engineered to facilitate controlled release of the antimicrobial agents. Also provided are methods for forming the provided hydrogels, and for using the hydrogels to treat a subject suffering from a microbial infection.
Claims38
A hydrogel comprising a plurality of amine-containing antimicrobial agents located within the interior of the hydrogel, wherein each of at least a portion of the amine-containing antimicrobial agents is connected to the hydrogel via one or more dynamic covalent imine bonds, and wherein the hydrogel is engineered to facilitate a controlled release of the amine-containing antimicrobial agents from the interior of the hydrogel.
Dependencies are inferred from the claim text.