Compositions of secretory and/or catalytic cells and methods using the same
AssigneeFlagship Pioneering Innovations VI, LLC
InventorsAlexandra Sophie DE BOER, Fabiana ZAPPALA, William Benjamin PEEPLES, Jordan Paul LEWANDOWSKI, Ayse Jane MUNIZ, Patrick Robert LUNDGREN
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Abstract
Disclosed herein are compositions comprising secretory and/or catalytic cells that are useful for the treatment, prevention, or amelioration of diseases or disorders.
Claims24
An allogenic, long-acting composition comprising a therapeutically effective amount of substantially pure secretory and/or catalytic cells, wherein the composition is modified for improved therapeutic efficacy relative to an unmodified composition, wherein the improved therapeutic efficacy is, upon administration to a subject, one or both of:
- increased immunotolerance or decreased immunogenicity, optionally wherein the composition is capable of treating, preventing, or ameliorating a disease or disorder in a subject in need thereof.
Dependencies are inferred from the claim text.