Benzothiazole compound and use thereof

A benzothiazole compound, having a structure represented by formula I, or a pharmaceutically acceptable salt, solvate, hydrate, polymorph, co-crystal, tautomer, stereoisomer, or isotope labeled compound thereof,

• wherein,
• R1 and R2 are independently selected from the group consisting of C1-C10 chain alkyl, C3-C8 cycloalkyl, C2-C8 chain alkenyl, C2-C8 alkynyl, C6-C20 aryl, C1-C20 heteroaryl, and C2-C20 heteroalicyclic group, wherein CH2 in the C1-C10 chain alkyl, C3-C8 cycloalkyl, C2-C8 chain alkenyl, and C2-C8 alkynyl can be replaced with one or more groups selected from the group consisting of —O—, —S—, —SO2—, —C(O)—, and —NR3—, and the C1-C10 chain alkyl, C3-C8 cycloalkyl, C2-C8 chain alkenyl, C2-C8 alkynyl, C6-C20 aryl, C1-C20 heteroaryl, and C2-C20 heteroalicyclic group are optionally substituted with one or more substituents selected from the group consisting of halogen atom, cyano, nitro, C6-C20 aryl, C1-C20 heteroaryl, C1-C10 chain alkoxy, C6-C20 aryloxy, C2-C20 heteroalicyclic group, amino, hydroxyl, mercapto,
• and —NR4R5;
• or
• R1 and R2, together with the N atom to which they are connected, form a heteroalicyclic group, preferably a C2-C20 heteroalicyclic group;
• or
• R1 is hydrogen, and R2 is selected from the group consisting of C1-C10 chain alkyl, C3-C8 cycloalkyl, C2-C8 chain alkenyl, C2-C8 alkynyl, C6-C20 aryl, C1-C20 heteroaryl, and C2-C20 heteroalicyclic group, wherein CH2 in the C1-C10 chain alkyl, C3-C8 cycloalkyl, C2-C8 chain alkenyl, and C2-C8 alkynyl can be replaced with one or more groups selected from the group consisting of —O—, —S—, —SO2—, —C(O)—, and —NR3—, and the C1-C10 chain alkyl, C3-C8 cycloalkyl, C2-C8 chain alkenyl, C2-C8 alkynyl, C6-C20 aryl, C1-C20 heteroaryl, and C2-C20 heteroalicyclic group are substituted with halogen atom, hydroxyl, mercapto, amino, nitro, cyano, carboxyl, acyl, C1-C10 alkoxy, C6-C20 aryl, C1-C20 heteroaryl, C2-C20 heteroalicyclic group, C1-C10 chain alkyl, C2-C8 chain alkenyl, or C2-C8 alkynyl, and wherein the substituents of at least two positions together form aliphatic ring, heteroalicyclic ring, aromatic ring, or heteroaromatic ring;
• R3, R4, and R5 are independently selected from the group consisting of hydrogen, aryl, heteroaryl, C1-C8 chain alkyl, C3-C8 cycloalkyl, C2-C8 chain alkenyl, and C2-C8 alkynyl, and the aryl and heteroaryl are optionally substituted with halogen atom, hydroxyl, mercapto, amino, nitro, cyano, carboxyl, acyl, alkoxy, aryl, heteroaryl, heteroalicyclic group, C1-C10 alkyl, C3-C8 cycloalkyl, C2-C8 chain alkenyl, or C2-C8 alkynyl, and wherein optionally the substituents of at least two positions together form aliphatic ring, heteroalicyclic ring, aromatic ring, or heteroaromatic ring;
• L is C1-C6 alkylene, and the alkylene is optionally substituted with halogen atom, hydroxyl, mercapto, amino, nitro, cyano, carboxyl, acyl, C1-C10 alkoxy, C6-C20 aryl, C1-C20 heteroaryl, C2-C20 heteroalicyclic group, C1-C10 alkyl, C3-C8 cycloalkyl, C2-C8 chain alkenyl, or C2-C8 alkynyl;
• R is adamantyl, and the adamantyl is optionally substituted with halogen atom, hydroxyl, mercapto, amino, nitro, cyano, carboxyl, acyl, C1-C10 alkoxy, C6-C20 aryl, C1-C20 heteroaryl, C2-C20 heteroalicyclic group, C1-C10 alkyl, C3-C8 cycloalkyl, C2-C8 chain alkenyl, or C2-C8 alkynyl;
• Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, Ri, Rj, Rk, Rl, Rm, Rp, Rq, and Rz are each independently selected from the group consisting of hydrogen, halogen substituted or unsubstituted C1-C8 chain alkyl, halogen substituted or unsubstituted C3-C8 cycloalkyl, halogen substituted or unsubstituted C2-C8 chain alkenyl, halogen substituted or unsubstituted C2-C8 alkynyl, halogen atom, hydroxyl, amino, nitro, cyano, carboxyl, acyl, and halogen substituted or unsubstituted C2-C8 alkoxy;
• preferably, the compound is represented b formula II:
• in formula II, the definitions to R1 and R2 are the same as those in formula I;
• preferably, the compound has the structure represented by formula I-1, formula 1-2, formula 1-3, formula 1-4, or formula 1-5,
• L1 is absent or —NHL3-, L3 is absent, or C1-C6 alkylene or C1-C6 alkylene substituted with halogen, hydroxyl, or C1-C6 alkoxy, preferably methylene, ethylene, or propylene;
• L2 is absent, or C1-C6 alkylene, or C1-C6 alkylene substituted with halogen, hydroxyl, or C1-C6 alkoxy, preferably methylene, ethylene, or propylene;
• Rb is H, deuterium, halogen, hydroxyl, NH2, carboxyl (—COOH), —CONH2, sulfonic acid group (—SO3H), —SO2—C1-C6 chain alkyl,
• C1-C6 chain alkyl, halogen-substituted C1-C6 chain alkyl, morpholine-substituted C1-C6 chain alkyl, —COO—C1-C6 chain alkyl, cyano, C1-C6 chain alkoxy, hydroxyl-substituted C1-C6 chain alkyl, amino-substituted C1-C6 chain alkyl, C3-C6 cycloalkyl, halogen-substituted C3-C6 cycloalkyl, hydroxyl-substituted C3-C6 cycloalkyl, phenyl, or benzyl;
• R′ each independently represents no substituent, single substituent, or multiple substituents, and each substituent is independently selected from the group consisting of H, deuterium, halogen, hydroxyl, NH2, carboxyl (—COOH), —CONH2, sulfonic acid group (—SO3H), —SO2—C1-C6 chain alkyl,
• C1-C6 chain alkyl, halogen-substituted C1-C6 chain alkyl, morpholine-substituted C1-C6 chain alkyl, —COO—C1-C6 chain alkyl, cyano, C1-C6 chain alkoxy, hydroxyl-substituted C1-C6 chain alkyl, amino-substituted C1-C6 chain alkyl, C3-C6 cycloalkyl, halogen-substituted C3-C6 cycloalkyl, hydroxyl-substituted C3-C6 cycloalkyl, phenyl, or benzyl;
• the definitions to the other symbols are the same as those in formula I.