Viral particles with fusogen display and related compositions and methods
AssigneeSana Biotechnology, Inc.
InventorsKyle Marvin TRUDEAU, Luca BIASCO
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Abstract
Provided herein are lipid particles containing a viral envelope attachment protein, such as derived from paramyxovirus or baboon endogenous virus (BaEV). In some embodiments, the lipid particles also contain a codisplay protein, such as a transduction adjuvant or an immune stimulating protein. Also provided are such lipid particles that are viral vectors, such as lentiviral vectors or lentiviral-like particles. Also provided are producer cells and compositions containing such lipid particles and methods of making and using the lipid particles.
Claims29
-291. (canceled)
A lipid particle, comprising:
- a. a Baboon Endogenous Virus (BaEV) fusogen or functional variant thereof, and
- b. a co-display protein comprising a binding means for specifically interacting with a target molecule expressed on the surface of a target cell;
- and
- wherein the protein in (a) and (b) are exposed on the outside of the lipid bilayer/embedded in the lipid bilayer.
A producer cell comprising (a) a nucleic acid encoding a retargeted attachment protein comprising a Baboon Endogenous Virus (BaEV) fusogen or functional variant thereof expressed on the surface of a target cell, and (b) a nucleic acid encoding a co-display protein.
Dependencies are inferred from the claim text.