A probe device for interfacing with cells such as neurons and associated devices, methods, and use

A probe device for interfacing with neurons in brain tissue, comprising a support structure having a longitudinal axis and a set of neuron interfacing electrodes arranged on said support structure,

• wherein said set of neuron interfacing electrodes is arranged and adapted to be movable between a first, insertion configuration and a second extended configuration, said first configuration being different from the second configuration,
• wherein said first configuration is adapted for reaching a predetermined target area in said brain while creating a minimal damage to said brain and
• wherein said second configuration corresponds to a predetermined regular 3-dimensional grid configuration, said predetermined regular 3-dimensional grid configuration corresponding to a cubic, face centered cubic (fcc), body centered cubic (bcc), or hexagonal grid configuration,
• wherein said neuron interfacing electrode comprises a sensing radius in brain tissue within the range of 75 micron to 150 micron, and
• wherein an electrode pitch of said neuron interfacing electrodes is within the range of 45 micron to 150 micron.