Reusable wearable ua biosensing system for prolonged monitoring and risk management of hyperuricemia

Abstract

The present invention discloses a wearable uric acid (UA) biosensing system comprising: a flexible printed circuit board; and a UA sensing patch attached on the flexible printed circuit board and including: an adhesive interface for on-demand removable adhesion to a skin region; an iontophoresis interface for facilitating stimulation and control of sweating of the skin region; a microfluid channel layer having a microchannel network with a plurality of microchannel inlets and a microchannel outlet for collecting sweat from the skin region; and an electrode layer including respective electrodes for sweat stimulation and UA concentration monitoring. The invention provides long-term stable and accurate uric acid monitoring through ratiometric long-life sensors resistant to by-product accumulation, a biocompatible and temperature-responsive hydrogel interface for comfortable wear, and integrated sweat induction and microfluidic collection, enabling reliable noninvasive hyperuricemia risk assessment and health management.

Dependencies are inferred from the claim text.