Therapy for the treatment of disorders in the nervous system using biomarkers

A system comprising:

• an implantable medical device (11) configured to be implanted into a patient (P);
• a wearable device (15) configured to be worn by the patient (P);
• at least one processor (13);
• at least a first electrode (110) in communication with the implantable medical device (11), the first electrode (110) configured to acquire at least a first electrical signal from a brain (B) or spinal cord of a patient;
• wherein the wearable device (15) is configured to generate a second signal relating to the patient (P);
• and
• wherein the at least one processor (13) is configured to:
• determine whether at least a first predetermined biomarker is present in at least one signal;
• whether at least a second predetermined biomarker is present in at least one signal;
• whether the first predetermined biomarker is present in the at least one first electrical signal and the second predetermined biomarker is present in the at least one second signal;
• and
• based on whether or not the first predetermined biomarker is present and whether or not the second predetermined biomarker is present and whether or not the first and the second predetermined biomarkers are present, either:
• adjusting at least one therapy parameter, or
• determining a patient state.