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AssigneeThe University of Tokyo
InventorsHiromitsu NAKAUCHI, Toshihiro KOBAYASHI, Younsu LEE, Joichi USUI, Tomoyuki YAMAGUCHI, Sanae HAMANAKA
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An object of the present invention is to produce a mammalian organ having a complicated cellular composition composed of multiple kinds of cells, such as kidney, pancreas, thymus and hair, in the living body of a non-human animal. The inventors of the present invention applied the chimeric animal assay described above, to a novel solid organ production method. More specifically, the inventors has shown that a model mouse which is deficient of kidney, pancreas, thymus or hair due to the dysfunction of the metanephric mesenchyme that is differentiated into most of an adult kidney, is rescued by blastocyst complementation by the chimeric animal assay, and whereby a kidney, a pancreas, thymus or hair can be newly produced.
A method for producing a target organ in the living body of a non-human mammal having an abnormality associated with a lack of development of the target organ in the development stage, the target organ being derived from an allogeneic and/or xenogeneic mammal that is an individual different from the non-human mammal, the method comprising:
A non-human mammal having an abnormality associated with a lack of development of a target organ in the development stage, produced according to a method comprising:
Use of a non-human mammal having an abnormality associated with a lack of development of a target organ in the development stage, for the generation of the target organ.
A set for producing a target organ, the set comprising:
Dependencies are inferred from the claim text.