System and method for predicting or characterizing immune responses

A non-transitory computer readable medium for characterizing immune responses of an immune system against a hepatitis B virus (HBV) infection, comprising instructions that, when executed by a processor, cause the processor to:

• (a) obtain input values for a plurality of parameters associated with the HBV infection for simulation;
• (b) generate a plurality of predicted quantitative values of the immune responses across one or more anatomical compartments by applying a quantitative system pharmacology (QSP) model to the input values of the plurality of parameters,
• wherein the QSP model integrates immune response components involved in HBV viral clearance across the one or more anatomical compartments in a single framework, and
• wherein the immune response components comprise innate immune response, adaptive immune response, and immunotolerant response;
• and
• (c) characterize the immune responses of the immune system based on the plurality of predicted quantitative values as leading to one of a self-resolution of an acute HBV infection, continuation of an acute status of the HBV infection, or evolution to a chronic status of the HBV infection.

A system for characterizing immune responses of an immune system against a hepatitis B virus (HBV) infection, comprising:

• (a) a parameter value module configured to obtain input values for a plurality of parameters associated with the HBV infection for simulation;
• (b) a module deployment module configured to generate a plurality of predicted quantitative values of the immune responses across one or more anatomical compartments by applying a quantitative system pharmacology (QSP) model to the input values of the plurality of parameters,
• wherein the QSP model integrates immune response components involved in HBV viral clearance across the one or more anatomical compartments in a single framework, and
• wherein the immune response components comprise innate immune response, adaptive immune response, and immunotolerant response;
• and
• (c) a response characterization module configured to characterize the immune responses of the immune system based on the plurality of predicted quantitative values as leading to one of a self-resolution of an acute HBV infection, continuation of an acute status of the HBV infection, or evolution to a chronic status of the HBV infection.