System and method for machine-learning based sensor analysis and vascular tree segmentation

A method for vascular assessment comprising:

• receiving a temporal sequence of angiographic images depicting a target vessel;
• applying one or more trained machine-learning models to the sequence to select at least one angiographic image from the sequence;
• segmenting, via the one or more trained machine-learning models, the selected at least one angiographic image to form vessel segmentation output indicating, at least, geometric dimensions;
• and
• determining, based at least on the geometric dimensions, fractional flow reserve (FFR) values associated with the target vessel.

A system comprising one or more processors and non-transitory computer storage media storing instructions that when executed by the one or more processors, cause the one or more processors to:

• receive a temporal sequence of angiographic images depicting a target vessel;
• apply one or more trained machine-learning models to the sequence to select at least one angiographic image from the sequence;
• segment, via the one or more trained machine-learning models, the selected at least one angiographic image to form vessel segmentation output indicating, at least, geometric dimensions;
• and
• determine, based at least on the geometric dimensions, fractional flow reserve (FFR) values associated with the target vessel.

Non-transitory computer storage media storing instructions that when executed by a system of one or more processors, cause the one or more processors to:

• receive a temporal sequence of angiographic images depicting a target vessel;
• apply one or more trained machine-learning models to the sequence to select at least one angiographic image from the sequence;
• segment, via the one or more trained machine-learning models, the selected at least one angiographic image to form vessel segmentation output indicating, at least, geometric dimensions;
• and
• determine, based at least on the geometric dimensions, fractional flow reserve (FFR) values associated with the target vessel.