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US 2026/0251646 A1Published application
Biosensor testing system and methods of use
AssigneesQuidel Corporation, University of Dayton
InventorsRichard L. Egan, Christopher Muratore
Life of this patent
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Abstract
A system comprised of a sensor chip and a reader is provided. The sensor chip has a sensing region with a detection agent that binds or associates with an analyte of interest in a sample. If present in the sample, interaction between the analyte of interest and the detection agent causes a change in resistance or conductivity of the sensing region, where the change or lack of change indicates presence or absence of the analyte of interest.
Claims54
A system, comprising:
- (a) a cassette comprising a sensor chip, the sensor chip comprised of a substrate with a first planar surface and a second planar surface, electrical contacts, a sensing region comprised of semiconducting transition metal, and a detection agent that interacts with an analyte of interest;
- and
- (b) a reader with a port configured to receive the cassette, the reader comprising a source of electrical current, a detector and a transmitter.
A method for detecting an analyte of interest, comprising:
- providing a cassette comprising a sensor chip comprised of a substrate with a first planar surface and a second planar surface, electrical contacts, a sensing region comprised of a semiconducting transition metal, and a detection agent that interacts with an analyte of interest;
- evaluating a first resistance of the sensing region;
- and
- contacting the sensing region with a sample suspected of comprising an analyte of interest that specifically binds the detection agent;
- evaluating a second resistance of the sensing region;
- and
- detecting binding of the analyte of interest to the detection agent if the second resistance is different from the first resistance.
4 more elements
A method for detecting an analyte of interest, comprising:
- providing a cassette comprising a sensor chip comprised of a substrate with a first planar surface and a second planar surface, electrical contacts, a sensing region comprised of a semiconducting transition metal, and a detection agent that interacts with an analyte of interest;
- inserting the cassette in a reader having a port configured to receive the cassette, the reader comprising a source of electricity, a detector, and a transmitter;
- measuring with the detector a first resistance of the sensing region by causing the source of electricity to apply electrical current to the electrical contacts;
- depositing a sample, or instructing to deposit a sample, on the cassette to cause sample to contact the sensing region;
- measuring with the detector a second resistance of the sensing region by causing the source of electricity to apply electrical current to the electrical contacts;
- and
- detecting binding of the analyte of interest to the detection agent if the second resistance is different from the first resistance.
4 more elements
Dependencies are inferred from the claim text.