Nanoplasmonic sensor

A method of making an array of nanomaterials comprising:

• coating a conductive photoresist layer onto a non-conductive substrate;
• patterning the conductive photoresist layer via lithography, thereby forming a patterned substrate;
• depositing an adhesion layer onto the patterned substrate;
• and
• depositing a metallic layer onto the adhesion layer.

A method of making a functionalized nanoplasmonic sensing chip comprising:

• providing a substrate comprising an array of sensors;
• affixing a micro-well adaptor on top of the substrate, thereby providing an array of micro-wells over and aligned with the array of sensors;
• forming one or more functionalized sensors in the array of sensors comprising:
• delivering a first batch of reaction solutions into one or more micro-wells atop one or more sensors;
• subsequently removing the first batch of reaction solutions from the one or more micro-wells;
• wherein the delivering and removing of the first batch of reaction solutions are performed by an automatic pipetting system;
• and
• removing the micro-well adaptor from the substrate.