Sequencing system with curved image plane or object plane
AssigneeIllumina, Inc.
InventorsSteve BOEGE, Rean Silke MUSA, Michael BUREK, Alexa HUDNUT
Life of this patent
Estimating the term…
Abstract
An apparatus includes a flow cell and an image sensor. The flow cell includes a plurality of reaction sites. The flow cell is configured to receive a fluid and an excitation light. Each reaction site is configured to contain a biological sample carried by the fluid. The reaction sites together are positioned along a reaction site plane. The image sensor is positioned to receive light emitted from the reaction site in response to the excitation light. The image sensor defines an imaging surface. The imaging surface defines an imaging surface plane. One or both of the reaction site plane or the imaging surface plane is curved.
Claims24
An apparatus, comprising:
- a flow cell comprising a plurality of reaction sites, the flow cell being configured to receive a fluid and an excitation light, each reaction site being configured to contain a biological sample carried by the fluid, the reaction sites together being positioned along a reaction site plane;
- and
- an image sensor positioned to receive light emitted from the reaction site in response to the excitation light, the image sensor defining an imaging surface, the imaging surface defining an imaging surface plane;
- the imaging surface plane being curved.
9-18. (canceled)
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28-29. (canceled)
32-75. (canceled)
A method comprising:
- communicating excitation light toward a biological sample on a floor of a reaction site in a flow cell;
- and
- receiving light emitted from the reaction site in response to the excitation light, the emitted light being received via an image sensor, the image sensor having an imaging surface, the image sensor including an imaging surface defining a curved plane.
A method comprising:
- communicating fluid through a flow cell, the flow cell having a first side and a second side, the flow cell comprising a plurality of reaction sites, each reaction site containing a biological sample carried by the fluid, the reaction sites together being positioned along a curved plane;
- communicating excitation light toward the biological samples at the reaction sites, the excitation light being communicated through the first side of the flow cell to reach the biological samples at the reaction sites;
- and
- receiving light emitted from the reaction sites along the curved plane in response to the excitation light, the emitted light being received via an image sensor, the emitted light passing through the first side of the flow cell to be received via the image sensor.
Dependencies are inferred from the claim text.