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US 2026/0250775 A1Published application
Assay for the detection of oropharyngeal cancer
AssigneeH. Lee Moffitt Cancer Center and Research Institute, Inc.
InventorAnna R. GIULIANO
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Abstract
Disclosed herein is an assay comprising a probe panel to detect the methylation status of 12 genes and one CPG site. Also disclosed herein are methods for using an oral wash and the probe panel to detect the presence of oropharyngeal cancer based on the methylation status of the genes and the CPG site.
Claims19
An assay for the detection of oropharyngeal cancer in a subject comprising probes to detect methylation at CpG sites in one or more genes in a tissue sample;
- wherein the genes comprise PAPD5, ST8SIA5, SNORD115-20, NCRNA00164;
- MIR663B, DDX42, RASA3, HMGB2, ARMC6, EPB41L3;
- and
- wherein a change in the amount of methylation of 3 or more CpG sites relative to a normal control indicates the presence of oropharyngeal cancer.
1 more element
A method of detecting oropharyngeal cancer in a subject, comprising:
- (i) obtaining a tissue sample from the subject;
- and
- (ii) measuring the methylation at CpG sites of one or more genes comprising PAPD5, ST8SIA5, SNORD115-20, NCRNA00164;
- MIR663B, DDX42, RASA3, HMGB2, ARMC6, and/or EPB41L3;
- wherein a change in the amount of methylation of 3 or more CpG sites relative to a normal control indicates the presence of oropharyngeal cancer.
2 more elements
A method of treating oropharyngeal cancer in a subject comprising:
- i) obtaining a tissue sample from the subject;
- ii) measuring the methylation at CpG sites of one or more genes comprising PAPD5, ST8SIA5, SNORD115-20, NCRNA00164;
- MIR663B, DDX42, RASA3, HMGB2, ARMC6, and/or EPB41L3;
- wherein a change in the amount of methylation of 3 or more CpG sites relative to a normal control indicates the presence of oropharyngeal cancer;
- and
- iii) treating the oropharyngeal cancer when detected.
3 more elements
Dependencies are inferred from the claim text.