Genetically modified microbial strain with increased tolerance to isoprenol
AssigneeThe Regents of the University of California
InventorsHyungyu LIM, Adam FEIST, Aparajitha SRINIVASAN, Aindrila MUKHOPADHYAY
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Abstract
The present invention provides for a genetically modified microbial strain capable of growing or dividing in a medium comprising equal to or more than about 4.5 g/L isoprenol, or having an increased tolerance to isoprenol compared to a unmodified microbial strain.
Claims9
A genetically modified microbial strain capable of growing or dividing in a medium comprising equal to or more than about 4.5 g/L isoprenol, or having an increased tolerance to isoprenol compared to a unmodified microbial strain, wherein the microbial strain comprises one or more mutations from the following gene/genetic region:
- gnuR (PP_3415), pcaK (PP_1376)-opdH, PP_3024-PP_5558, erdR (PP_1635) or mxtR (PP_1695), oprD (PP_1206)/PP_1207, infC (PP_2466), astA-II (PP_4480), topA (PP_2139), PP_2402-calA (PP_2426), PP_3595-PP_3610, rpoZ (PP_5301), and/or fleQ, and any gene/genetic region described herein, such as in Table 1.
Dependencies are inferred from the claim text.