Conjugate compositions comprising phosphoryl guanidine linkages and uses thereof

A conjugate of Formula (I):

• wherein,
• A is a binding moiety;
• B is a double-stranded oligonucleotide comprising a guide strand and a passenger strand;
• X is a bond or a linker;
• n is a number≥2;
• and
• wherein the guide strand or the passenger strand comprises at least one modified internucleotide linkage comprising the structure of Formula (II):
• wherein each R11, R12, R13, and R14 is independently selected from —H, —C1-10 alkyl, —C2-10 alkenyl, —C2-10 alkynyl, or —C6-10 aryl;
• optionally, wherein R12 and R13, together with an atom to which they are bound, form a 5-8 membered heterocyclic substituent moiety, selected from the group consisting of N-pyrrolidinyl, N-piperidinyl, N-azepanyl, N-azocanyl, and imidazolidine.