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US 2026/0250477 A1Published application
Porous Polymer Scaffolds, and Methods of Making and Using the Same
AssigneeThe Regents of the University of California
InventorsTejal A. Desai, Ryan Chang, Jasper Z. Williams
Life of this patent
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Abstract
Polycaprolactone (PCL) scaffolds having macropores interconnected with micorpores are provided. Tissue grafts that include the PCL scaffold having therapeutic cells encapsulated within the macropores are also provided. Also provided are methods of making the PCL scaffold and the tissue graft, and methods of transplanting cells into an individual using the tissue graft.
Claims21
1-58. (canceled)
A method of making a polymeric scaffold, comprising:
- combining:
- a polycaprolactone (PCL) solution comprising PCL dissolved in a solvent;
- and
- a porogen,
- under conditions sufficient to generate a mixture comprising a supersaturated solution of the porogen;
- depositing the mixture on a support;
- removing the solvent from the deposited mixture, to generate a PCL matrix;
- and
- removing the porogen from the PCL matrix, to produce a polymeric scaffold comprising a plurality of pores,
- wherein the plurality of pores comprise macropores interconnected by micropores.
7 more elements
69-75. (canceled)
Dependencies are inferred from the claim text.