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US 2026/0250467 A9Published application
Hybrid polymers and compositions including the same
OwnerTheresa M. Reineke, Punarbasu Roy +1inventors
InventorsTheresa M. Reineke, Punarbasu Roy, Nicholas W. Kreofsky
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Abstract
A hybrid polymer may include a hydrophilic block polymerized from a hydrophilic monomer and a hydrophobic block polymerized from at least a quinoline-containing monomer. Polyplex transfection complexes that include a hybrid polymer and an oligonucleotide. Compositions that include a polyplex transfection complex. Methods of using a composition to transfect a cell.
Claims20
A hybrid polymer comprising:
- a hydrophilic block polymerized from a hydrophilic monomer;
- and
- a hydrophobic block polymerized from at least a quinoline-containing monomer of the structure
- wherein:
- RA is H or OCH3;
- n1 is an integer from 1 to 5;
- Y is H or CH3;
- and
- X is
- wherein:
- R3, R4, and R5, are each independently O, NH, NR20, or S;
- wherein R20 is methyl, ethyl, or propyl;
- R1 and R2 are each independently H or alkyl;
- and
- n2 is an integer from 1 to 10.
12 more elements
Dependencies are inferred from the claim text.