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US 2026/0250413 A1Published application
Lung cancer targeting human antibodies and therapeutic uses thereof
AssigneeIstituto Romagnolo Per Lo Studio Dei Tumori "Dino Amadori" - Irst S.R.L.
InventorsMassimiliano MAZZA, Fabio NICOLINI, Anna GAIMARI, Lucia MAZZOTTI, Anna DE LUCIA
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Abstract
The present invention relates to antibodies or antigen binding fragments thereof targeting in particular lung cancer and to pharmaceutical compositions containing said antibodies, and uses thereof.
Claims18
An isolated antibody or antigen binding fragment thereof comprising:
- a. a heavy chain variable domain (VH) comprising:
- i. a CDR1 sequence of an amino acid sequence of:
- SEQ ID NO.1;
- ii. a CDR2 sequence of an amino acid sequence of SEQ ID NO. 2;
- and
- iii. a CDR3 sequence of an amino acid sequence selected from the group consisting of SEQ ID NO. 4, 3 and 5 and/or
- b. a light chain variable domain (VL) comprising:
- i. a CDR1 sequence of an amino acid sequence selected from the group consisting of:
- SEQ ID NO. 9, 6 and 12;
- ii. a CDR2 sequence of an amino acid sequence selected from the group consisting of:
- SEQ ID NO. 10, 7 and 13;
- and
- iii. a CDR3 sequence of an amino acid sequence selected from the group consisting of:
- SEQ ID NO. 11, 8 and 14.
11 more elements
(canceled)
Dependencies are inferred from the claim text.