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US 2026/0250393 A1Published application
METHODS FOR TREATING IgG4-RELATED DISEASES
AssigneeXencor, Inc.
InventorsDebra Zack, John H. Stone, Shiv Pillai
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Abstract
The present disclosure relates to immunoglobulins that bind FcγRIIb+ B cells and coengage CD19 on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins for the treatment of an IgG4-related disease.
Claims11
A method of treating IgG4-related disease (IgG4-RD) comprising administering a therapeutically effective amount of an anti-CD19 antibody to a subject in need thereof, wherein the anti-CD19 antibody comprises
- a light chain variable region of SEQ ID NO:
- 1;
- a heavy chain variable region of SEQ ID NO:
- 2;
- and
- an Fc region comprising S267E and L328F substitutions, wherein numbering is according to the EU index as in Kabat,
- wherein the therapeutically effective amount ranges between 125 mg and 375 mg.
4 more elements
Dependencies are inferred from the claim text.