Methods for detecting or treating atherosclerosis

Abstract

The current disclosure provides sensitive diagnostic methods that do not require invasive angiography. It was found that TNFAIP2 was secreted into the sera of subjects with atherosclerosis. This novel biomarker can be used to detect early-stage atherosclerosis. Accordingly, aspects of the disclosure relate to a method for measuring a TNFAIP2 level comprising: obtaining a biological sample from a subject having, suspected of having, or at risk of having atherosclerosis; and measuring the TNFAIP2 level in a biological sample from the subject as compared to a control. Also disclosed is a method for treating or preventing atherosclerosis in a subject, the method comprising administering an effective amount of a treatment for atherosclerosis to the subject after measuring the TNFAIP2 level in a biological sample from the subject as compared to a control.

Dependencies are inferred from the claim text.