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US 2026/0250340 A1Published application
Sfgf1-fgf21: a chimeric protein with increased stability and biological activities
OwnerPhuc PHAN, Deborah OKYERE +4inventors
InventorsPhuc PHAN, Deborah OKYERE, Divya GOLLAPALLI, Jingyi CHEN, Kyle QUINN, Suresh THALLAPURANAM
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Abstract
The present invention provides fusion proteins comprising a fibroblast growth factor 1 (FGF1) peptide and a fibroblast growth factor 21 (FGF21) peptide. Pharmaceutical compositions and wound dressings comprising the fusion proteins, polynucleotides encoding the fusion proteins, and methods of using the fusion proteins to treat a condition in a subject are also provided.
Claims20
A fusion protein comprising:
- a) a fibroblast growth factor 1 (FGF1) peptide having at least 95% sequence identity to SEQ ID NO:
- 1;
- and
- b) a fibroblast growth factor 21 (FGF21) peptide having at least 95% sequence identity to SEQ ID NO:
- 3 or a fragment thereof comprising 30-200 amino acid residues.
2 more elements
Dependencies are inferred from the claim text.