Hybrid antimicrobial peptides
AssigneesUniversidade Federal Do Abc, The Trustees of the University of Pennsylvania
InventorsCésar DE LA FUENTE-NUNEZ, Marcelo DER TOROSSIAN TORRES, Vani Xavier DE OLIVEIRA JUNIOR, Cibele NICOLASKI PEDRON
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Abstract
Provided herein are hybrid antimicrobial peptides, as well as methods for making such hybrid peptides, and methods treating microbial infections using the hybrid peptides.
Claims17
A method for preparing a hybrid antimicrobial peptide comprising:
- selecting a parent peptide having antimicrobial activity and a portion that represents a helical structure when contacted with a cell membrane bilayer;
- selecting a template peptide having antimicrobial activity and a portion that represents a helical structure when contacted with a cell membrane bilayer;
- combining a hydrophilic face of the helical structure of the parent peptide with the hydrophobic face of the helical structure of the templated peptide, or combining a hydrophobic face of the helical structure of the parent peptide with the hydrophilic face of the helical structure of the template peptide, thereby forming a hybrid helical structure, wherein the hybrid antimicrobial peptide comprises the hybrid helical structure.
A hybrid antimicrobial peptide comprising a hybrid helical portion comprising a combination of a hydrophobic face of a parent antimicrobial peptide and a hydrophilic face of a template antimicrobial peptide, or a combination of a combination of a hydrophilic face of the parent antimicrobial peptide and a hydrophobic face of the template antimicrobial peptide.
Dependencies are inferred from the claim text.