Lung-Specific Targeting-Peptide (LTP), Compositions, and Uses Thereof
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorMaliha Zahid
Life of this patent
Estimating the term…
Abstract
Disclosed is a synthetic, non-naturally occurring 12-amino acid peptide, Lung-specific Targeting Peptide, belonging to the larger class of cell penetrating peptides, for delivery of both diagnostic and potentially therapeutic agents to the lung. Also disclosed are methods of treating pulmonary disease, e.g., chronic obstructive pulmonary disease (COPD), emphysema, chronic bronchitis, asthma, primary ciliary dyskinesia (PCD), cystic fibrosis (CF), and lung cancer.
Claims20
A method of introducing a drug or therapeutic, a nanoparticle, a peptide, a protein, a nucleic acid, or a detectable agent into a lung epithelial cell, comprising administering to the lung epithelial cell a recombinant and isolated Lung-specific Targeting-Peptide (LTP) of the sequence of SEQ ID NO:
- 1 or 2 connected to the drug or therapeutic, nanoparticle, peptide, protein, nucleic acid, or detectable agent.
A formulation comprising a lung-penetrating peptide (LTP) of SEQ ID NO:
- 1 or 2 connected to a drug or therapeutic, nanoparticle, peptide, protein, nucleic acid, or detectable agent, and a pharmaceutically acceptable carrier.
A cyclic peptide comprising an amino acid sequence of any one of SEQ ID NOs:
- 1-14, wherein an N-terminal lysine is added to the amino acid sequence, wherein the N-terminal lysine connects to the C-terminus of the amino acid sequence.
Dependencies are inferred from the claim text.