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AssigneeAmgen Inc.
InventorsMatthew G. Beaver, Sebastien Caille, Charles Joseph Dooley, III, Hsiao-Wu Hsieh, Heather Claire Johnson, Neil Fred Langille, James Murray, Tessa Hamilton Trexler Myren
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The disclosure provides processes for a cross-coupling reaction comprising (a) exposing a mixture comprising a nickel (11) precatalyst, a phosphine, and an electrolyte in a solvent to a current to produce a nickel (0) catalyst; and (b) catalyzing the cross-coupling reaction with the nickel (0) catalyst. The disclosure also provides processes for preparing Compound (A), or a salt thereof, Compound (F), and Compound (I), as described herein.
A process for a cross-coupling reaction comprising (a) exposing a mixture comprising a nickel(II) precatalyst, a phosphine, and an electrolyte in a solvent to a current to produce a nickel(0) catalyst;
A process for preparing Compound A, or a salt thereof:
A process for preparing Compound F
Dependencies are inferred from the claim text.