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US 2026/0250293 A1Published application
Ulodesine salt
AssigneeLaevoroc Immunology AG
InventorsYao Han, Xianfeng Chai, Juan Liu, Quihong Luo, Thomas Mehrling
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Abstract
The present disclosure relates specifically to novel glutarate salt forms of Ulodesine or the compound known as 7-[(3R, 4R)-3-Hydroxy-4-hydroxymethyl-pyrrolidin-1ylmethyl]-5-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one and methods of preparing the same.
Claims9
A pharmaceutically acceptable salt of a ulodesine compound:
- wherein the salt comprises at least one salt selected from a glutarate, a malonate, and/or an oxalate salt.
A method of preparing a ulodesine hemi-glutarate salt or a ulodesine hemi L-glutarate salt, comprising the steps:
- (a) preparing a solution of ulodesine free base in water, and optionally stirring at room temperature;
- (b) adding glutarate acid, or L-glutarate acid to the mixture of step (a), and optionally stirring for 30 min at room temperature;
- (c) freeze-drying the solution of step (b) to yield a white solid product;
- (d) dissolving the solid product of step (c) in water;
- optionally heating up to 75° C.;
- adding ethanol and optionally stirring at 75° C. for 30 minutes, to form a homogeneous solution;
- (e) making a dropwise addition of acetonitrile to the solution of step (d), optionally over a period of 60 minutes;
- (f) stirring the solution of step (e) for 60 minutes, optionally at 75° C.;
- and optionally cooling the solution to 0° C. over a period of 60 minutes;
- (g) filtering and washing with acetonitrile to obtain the ulodesine hemi-glutarate salt or the ulodesine hemi L-glutarate salt.
7 more elements
Dependencies are inferred from the claim text.