Analogs for the treatment of disease

A method of treating a fibrotic disease or condition, comprising administering a compound represented by Formula (IIA)

• wherein:
• R1 is selected from
• substituted C1-C6 alkyl, wherein the C1-C6 alkyl is substituted with one or more substituents selected from halogen, —OH, —CN, —NO2, —NH2, oxo, ═S, —C1-10 haloalkyl, —O—C1-10 alkyl, —O—C1-6alkyl-O—C(O)(O—C1-10 alkyl), C2-10 alkenyl, C2-10 alkynyl, C3-12 carbocycle, and 3- to 12-membered heterocycle;
• and
• optionally substituted 3 to 8-membered heterocycle, wherein the 3 to 8-membered heterocycle is optionally substituted with one or more substituents selected from halogen, —OH, —CN, —NO2, —NH2, oxo, ═S, —S(O2)NH2, —C1-10 haloalkyl, —O—C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-12 carbocycle, 3- to 12-membered heterocycle, and optionally substituted C1-10 alkyl, wherein the C1-10 alkyl is optionally substituted with one or more substituents selected from hydroxy, halogen, oxo, —C1-10 haloalkyl, —NH2, —CN, and —NO2;
• R3 is optionally substituted C3-10 carbocycle, which is optionally substituted with one or more substituents selected from halogen, —OH, —CN, —NO2, —NH2, oxo, ═S, C1-6 alkyl, —C1-10 haloalkyl, —O—C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-12 carbocycle, and 3- to 12-membered heterocycle;
• and
• R4 is non-halogenated C1-C6 alkyl,
• or a pharmaceutically acceptable salt thereof, to a subject in need thereof.

A compound represented by Formula (A):

• or a pharmaceutically acceptable salt thereof, wherein:
• Z is selected from optionally substituted 3- to 12-membered heterocycle and optionally substituted C3-C12 carbocycle, wherein the substituents on each are independently selected at each occurrence from one or more —N(R10)2, halogen, —OH, —CN, —NO2, —NH2, oxo, ═S, —C1-10 haloalkyl, —O—C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C1-C10 alkyl, C3-12 carbocycle, and 3- to 12-membered heterocycle;
• wherein the C1-C10 alkyl is optionally substituted with one or more substituents independently selected at each occurrence from halogen, —OH, —CN, —NO2, —NH2, oxo, ═S, —C1-10 haloalkyl, —O—C1-10 alkyl, —O—C1-6alkyl-O—C(O)(O—C1-10 alkyl), C2-10 alkenyl, C2-10 alkynyl, C3-12 carbocycle, and 3- to 12-membered heterocycle;
• wherein the C3-12 carbocycle and 3- to 12-membered heterocycle are each optionally substituted at each occurrence from one or more substituents independently selected from halogen, —OH, —CN, —NO2, —NH2, oxo, ═S, —S(O2)NH2, —C1-10 haloalkyl, —O—C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-12 carbocycle, and 3- to 12-membered heterocycle, and optionally substituted C1-10 alkyl, wherein the optional substituents on the C1-10 alkyl are independently selected at each occurrence from one or more hydroxy, halogen, oxo, —C1-10 haloalkyl, —NH2, —CN, and —NO2;
• R10 is selected from optionally substituted C1-C6 alkyl, wherein the optional substituents on C1-C6 alkyl are independently selected at each occurrence from one or more halogen, —OH, —CN, —NO2, —NH2, oxo, ═S, —C1-10 haloalkyl, —O—C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-12 carbocycle, 3- to 12-membered heterocycle;
• W is selected from optionally substituted 5- to 8-membered heterocycle and optionally substituted C3-C8 carbocycle, wherein the substituents on each are independently selected at each occurrence from one or more halogen, —OH, —CN, —NO2, —NH2, oxo, ═S, —C1-10 haloalkyl, —O—C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-12 carbocycle, 3- to 12-membered heterocycle, wherein the C3-12 carbocycle and 3- to 12-membered heterocycle are each optionally substituted with one or more substituents independently selected at each occurrence from halogen, —OH, —CN, —NO2, —NH2, oxo, ═S, C1-10 alkyl, —C1-10 haloalkyl, and —O—C1-10 alkyl;
• and
• Y is selected from optionally substituted 5- to 8-membered heterocycle and optionally substituted C3-C8 carbocycle, wherein the substituents on each are independently selected at each occurrence from one or more halogen, —OH, —CN, —NO2, —NH2, oxo, ═S, —C1-10 haloalkyl, —O—C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-12 carbocycle, 3- to 12-membered heterocycle, wherein the C3-12 carbocycle and 3- to 12-membered heterocycle are each optionally substituted with one or more substituents independently selected at each occurrence from halogen, —OH, —CN, —NO2, —NH2, oxo, ═S, C1-10 alkyl, —C1-10 haloalkyl, and —O—C1-10 alkyl.