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US 2026/0250253 A1Published application
Method for producing 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol
AssigneeBASF Agro B.V.
InventorsDavid A. Harney, David A. Cortes, Franklin Brice Caldwell, Keith W. Rosenkrans, Przemyslaw Mariusz Lusiak, Ryan Michael Phillips
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Abstract
The present invention relates to a method for producing 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol in high purity and yield.
Claims8
A method for obtaining 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol of formula (I) from a mixture containing 2_compound of formula (I) and 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1,2,4-triazol-4-yl)propan-2-ol of formula (I-sym)
- comprising
- (a) providing a mixture containing the compounds of formulae (I) and (I-sym) in at least one aromatic solvent, where the mixture contains the compound of formula (I) in a concentration of from 30 to 90% by weight, relative to a total weight of the mixture;
- (b) adding to the mixture of step (a) at least one polar aprotic solvent, so that it is contained in an amount of from 1 to 25% by weight, relative to a weight of the solution obtained after the addition of the at least one polar aprotic solvent;
- (c) crystallizing the compound of formula (I) from the mixture obtained in step (b);
- (d) adding to a mother liquid obtained after crystallization in step (c) water in an amount of from 10 to 40% by weight, relative to a total weight of the mother liquid;
- and
- (e) separating a liquid phase from the mixture obtained in step (d) and returning a separated liquid phase to step (a).
4 more elements
Dependencies are inferred from the claim text.