Selective Serotonin Receptor Modulators and Methods of Making and Using the Same

A method of treating a seizure disorder in a subject having absence seizures, comprising administering to the subject a therapeutically effective amount of at least one compound of Formula I:

• wherein
• X and Y are each hydrogen;
• W1 is O;
• W2 is C(R3)(R3′);
• Z4 is CR4;
• Z5 is CR5;
• Z6 is CR6;
• Z7 is CR7;
• R2 is a C1-C4 alkyl optionally substituted with one or more groups selected from deuterium and halo;
• R3 and R3′ are each, independently, selected from hydrogen and deuterium;
• R4, R6, and R7 are each independently selected from hydrogen and deuterium;
• R5 is fluoro;
• Group A is cyclopropyl, wherein the is a single bond and wherein Rx and Rw are each, independently, selected from hydrogen and deuterium;
• and salts, solvates, hydrates, prodrugs, and enantiomers thereof.