Nmr tube assembly and filling method therefor

A method for loading a liquid sample into an NMR tube, the method comprising:

• attaching a closure to an NMR tube to form an NMR tube assembly, the closure comprising a reservoir chamber and the NMR tube having a cavity;
• introducing a liquid sample into the reservoir chamber of the closure of the NMR tube assembly, the liquid sample being maintained in the reservoir chamber of the closure and being prevented from passively flowing into the cavity of the NMR tube to which the closure is attached;
• and
• subjecting the NMR tube assembly to a centrifugal force to transfer the liquid sample from the reservoir chamber of the closure into the cavity of the NMR tube.

A closure for an NMR tube, the closure comprising:

• a top end having a first opening;
• a bottom end having a second opening;
• a bore that extends from the first opening in the top end to the second opening in the bottom end, the bore comprising a reservoir chamber located adjacent to the first opening, the reservoir chamber comprising a tapered funnel section having a taper angle between 55° and 70°;
• and
• wherein the closure is configured to be coupled to the NMR tube to form an NMR tube assembly, and wherein a liquid sample received in the reservoir chamber is configured to be held in the reservoir chamber until transferred into the NMR tube by subjecting the NMR tube assembly to a centrifugal force.