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US 2026/0249270 A1Published application
Monolithic microporous substrate for chromatographic beds
OwnerRobert S. Zeller, Gaston De Los Reyes +1inventors
InventorsRobert S. Zeller, GASTON DE LOS REYES, ERIK O. BLOMQUIST
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Abstract
Methods and devices are disclosed for a separation device including a sintered polymeric monolith having polymeric microparticulate solids with a pore size from about 0.5 to about 8 microns, a porosity between about 50 percent to about 80 percent and a chromatographic uniformity characterized by an HETP (height equivalent of a theoretical plate) less than about 100 microns.
Claims11
A method of making a polymeric monolithic microporous substrate comprising:
- air-laying a microparticulate solid into a mold of predetermined dimensions comprising:
- dispensing the microparticulate solid on a screen;
- sifting the microparticulate solid through the screen and into a mold forming a dry bed of microparticulate solid greater than about 1.0 mm thick;
- compressing the dry bed of microparticulate solid in the mold such that the dry bed of microparticulate solid has a porosity greater than 50 percent;
- and
- sintering the dry bed of microparticulate solid in the mold at a temperature below a melting point of the microparticulate solid to form a monolithic microporous substrate having an average pore size from about 0.5 μm to about 10 μm, a porosity of 50~80 percent and a thickness greater than 1.0 mm.
3 more elements
A method of making a monolithic microporous substrate comprising:
- dispersing a microparticulate solid in a liquid to form a slurry;
- wet-laying the dispersed microparticulate solid into a mold, comprising:
- adding the dispersed microparticulate solid into a slurry reservoir having a mold of predetermined dimensions, the mold further comprising a slurry filter to enable the liquid in the dispersed microparticulate solid to filter out of the mold while retaining the microparticulate solid;
- building a packed bed of dispersed microparticulate solid having a thickness greater than 1.0 mm;
- compressing the packed bed of microparticulate solid in the mold to a porosity greater than 50 percent;
- drying the packed bed of microparticulate solid;
- and
- sintering the packed bed of microparticulate solid in the mold to form a monolithic microporous substrate having an average pore size of about 0.5 to about 10 μm, a porosity of about 50 percent to about 80 percent and a thickness greater than 1.0 mm.
5 more elements
Dependencies are inferred from the claim text.