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AssigneeCVRx, Inc.
InventorsPhilip B. Adamson, Paul Pignato, Tucker Stuart, Bart Carey, Seth J. Wilks, Y-Lan Nguyen Cruea
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This disclosure presents systems and methods for baroreflex activation therapy (BAT) to regulate inflammation by modulating autonomic nervous system activity. Electrical stimulation is delivered to one or more baroreceptors, and real-time physiological signals are monitored, including inflammatory biomarkers (e.g., TNF-α, IFN-γ, IL-1, IL-6, IL-12, CRP) and autonomic parameters such as heart rate variability (HRV). A closed-loop feedback module analyzes biomarker fluctuations and autonomic balance changes and dynamically modifies stimulation parameters, including amplitude, pulse width, frequency, and duty cycle, to suppress systemic inflammation and restore autonomic balance. In certain embodiments, multi-channel stimulation architectures and AI-driven algorithms or machine learning models analyze biomarker trends and historical patient response patterns to optimize therapy. The disclosed BAT systems and methods may be used to treat inflammatory diseases, autoimmune disorders, cancer progression, chronic inflammatory pain conditions, arrhythmias associated with inflammation, and metabolic dysfunction.
A method for regulating inflammation in a patient using baroreflex activation therapy, comprising:
A baroreflex activation therapy system for modulating inflammation, comprising:
A method for treating an arrhythmia associated with inflammation using baroreflex activation therapy, comprising:
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