Ingestible device for delivery of therapeutic agent to the gastrointestinal tract

A method of treating a disease or condition in a subject, comprising:

• orally administering an ingestible device containing a dispensable substance to the subject;
• releasing compressed gas from a pre-pressurized compressed gas container;
• the released compressed gas contacting and acting on a piston causing the dispensable substance to be ejected from the ingestible device in the gastrointestinal tract of the subject as at least one jet, providing trans-epithelial administration of the dispensable substance;
• and
• wherein the disease is responsive to treatment with the dispensible substance.